To understand the seismicity in Myanmar, detailed analysis of hypocenters and fault planes determination are important. First, we relocated seven earthquakes of which magnitudes are Mw > 6.0, together with their aftershocks using modified joint hypocenter determination (MJHD) method and used P-wave arrival times from International Seismological Centre (ISC). We relocated aftershocks of one day, one week, or one month based on the aftershocks’ occurrences. Target area is + 1 degree from both the latitude and longitude from Global CMT for each large earthquake. After the relocations of the large earthquakes and their aftershocks, we could identify the fault plane of three earthquakes but some earthquakes are difficult to identify the fault plane due to aftershocks occurrences. Furthermore, we relocated earthquakes including the historical earthquakes to investigate the seismicity along the Sagaing fault. We used P-wave arrival times from ISC (1961 to March, 2007) and those for seven historical earthquakes from International Seismological Summary (ISS). Once the hypocenters relocated precisely, the earthquakes occurrence and seismic gap along the Sagaing fault would become clear. Some relocated epicenters are closer to the fault than those before relocation. We could determine the hypocenters of historical earthquakes and recent earthquakes on the five sub-regions. It means our results are consistent with the geological setting of this region and are useful for seismic hazard assessment in this region.