In order to make clear the effect of topography and slope structure on seismic performance of the slopes, which are similar to the slopes around Shimane nuclear power plant (Shimane NCPP), using ABAQUS FEM software, after confirmed the validity of the method used in the study by existing centrifuge test of a slope, two kinds of slope models are built based on the results of field geological investigation of the slopes around Shimane NCPP. Three homogenous slope models with a same height of 100 m and different slope angles as 20 deg., 30 deg. and 40 deg. are built to study the effect of the slope angle. Three homogenous slope models with a same slope angle of 30 deg. and different slope heights as 75 m, 100 m and 150 m are built to study the effect of the slope height. Four alternately distributing layered slope models with a same height of 100 m, a same slope angle of 30 deg. and different dip angles as 10 deg., 20 deg., 30 deg. and 40 deg. are built to study the effect of the dip angle. The 2000 Western Tottori M7.3 earthquake is taken as input seismic motion to study the amplification of seismic acceleration, and two times enlarged 1995 M7.2 Kobe earthquake is taken as input seismic motion to study the possible slope failure styles. The results indicated that, (a) the seismic acceleration amplification of the slope top increases with the slope angle decreasing and the slope height increasing, and the amplification becomes larger duo to the existing slope structure, (b) When a homogenous slope gets damaged, the slope angle controls the sliding face angle, while the slope height almost has no influence. (c) When a slope with structure gets damaged, the slope with a smaller dip angle than the slope angle slides along the softer layers, while the slope with a larger dip angle than the slope angle activates as the corresponding homogenous slope.