The purpose of this study is to evaluate the site response on ground motion in the urban area of Managua, Nicaragua, considering nonlinear behavior of the subsoil, using the program EERA, which is based on the equivalent linear soil model. The site response models were constructed using shear wave profiles, which were obtained by applying a geophysics method (MASW) in the target area, geotechnical and geological data available at the sites. The numerical simulation programs used in this study can be downloaded from http://gees.usc.edu/GEES/ . In this study, seven site response analyses were carried out using the input ground acceleration recorded during the 1972 Managua Earthquake. Based on the EERA analyses results, the ground motion in the target area is strongly affected by the first ten meters of soil which are mainly composed of silty sand, classified as "moderate soft soil", with shear wave velocity between 180 m/s and 360 m/s. Comparing the response acceleration spectrum obtained at each site with the design acceleration spectrum, provided by the Nicaragua Seismic Code, the design spectrum for the Managua area can be considered as overestimated. In addition, the liquefaction potential was evaluated in two cases with different water levels. In both cases, the liquefaction is supposed to occur between the depths 2.1 and 5.6 meters, corresponding to the layers composed mainly for silty sand. The severity of the liquefaction expected is classified as moderate to minor liquefaction, according to the liquefaction potential index estimated.